| Active substance | Methotrexate |
|---|---|
| Water Retention | None |
| Hepatotoxicity | High, requires regular liver function monitoring |
| Lab Test | Regular monitoring of blood counts and liver function tests |
| Strength | 2.5mg |
| Also known as | MTX, Amethopterin |
| Blood pressure | No direct effect |
| Trade name | Trexall, Rheumatrex |
| Storage conditions | Store at room temperature away from light and moisture |
| Chemical name | Methotrexate |
| Formula | C20H22N8O5 |
| Substance class | Antimetabolite, specifically a folate analog |
| Main action | Inhibits dihydrofolate reductase, leading to a decrease in DNA synthesis and cell reproduction |
| Half-life | 3 to 10 hours (variable) |
| Dosage (medical) | Typically 7.5 mg once weekly for rheumatoid arthritis, varying doses for cancer treatment depending on protocol |
| Dosage (sports) | Not applicable |
| Effects | Reduces activity of the immune system and interferes with growth of cancer cells |
| Side effects | Nausea, vomiting, liver toxicity, lung disease, increased risk of infection, mucositis, alopecia |
| Use in sports | Not typically used in sports |
| Manufacturer | Johnlee Pharmaceuticals Pvt. Ltd. |
| Packing | 10 tabs/blister |
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